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| Protein identified that can result in fragile bones -- EurekAlert
Too little of a protein called neogenin results in a smaller skeleton during development and sets the stage for a more fragile bone framework lifelong. A developing mouse with neogenin deficits has poorly defined digits and is generally smaller, including having small growth plates, an indicator of future development. Their findings provide new insight into skeletal development as they point toward a potential new direction for treating osteoarthritis, a common, painful and debilitating condition where cartilage between bones is lost. |