Mutations of the gene responsible for expressing LRRK2 have been linked to an increased risk of Parkinson's and Crohn's diseases; the researchers found that five of the six most common pathogenic mutations of LRRK2 affect its ability to bind with 14–3–3 proteins and alter cellular localization –– but not kinase activity –– of LRRK2. The mutated forms of LRRK2 that fail to bind 14–3–3 proteins accumulate within discrete cytoplasmic pools perhaps res ... Click Here to Read More Click Here to Read More
